3/20/2023 0 Comments Vitamin b 12 500 mcgHowever, more recent studies are needed to support this claim ( 8, 9).Īnother study in pregnant women showed that extremely high B12 levels due to vitamin supplements increased the risk of autism spectrum disorder in their unborn child ( 10). What’s more, the participants receiving the high dose B vitamins had a greater risk of heart attack, stroke, and death, compared to those receiving a placebo. One 2010 study found that people with diabetic nephropathy (loss of kidney function due to diabetes) experienced a more rapid decline in kidney function when supplemented with high dose B vitamins, including 1 mg per day of B12 ( 8). There is also some evidence suggesting that high doses of B12 may lead to negative health outcomes in those with diabetes or kidney disease. Yet, it should be noted that most of these studies focused on high dose injections rather than oral supplements ( 5, 6, 7). Several studies have shown that megadoses of the vitamin can lead to outbreaks of acne and rosacea, a skin condition that causes redness and pus-filled bumps on the face. However, supplementing with excessively high levels of B12 has been linked to some negative side effects. This threshold has not been set for B12 because your body excretes whatever it doesn’t use through your urine. UL refers to the maximum daily dose of a vitamin unlikely to cause adverse side effects in the general population. No Tolerable Upper Intake Level (UL) has been established for B12, due to its low level of toxicity. Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. Is taking high doses of B12 helpful or harmful? Supplements may help boost mood and reduce symptoms of depression in those who are not deficient in this vitamin. Summaryī12 is an important nutrient that is essential for red blood cell formation, DNA synthesis, and many other vital processes. However, B12 supplements will most likely increase energy levels in those who are deficient, as this nutrient plays an important role in converting food into energy. Treatment with a supplement containing a high dose of B12 for 60 days significantly improved depression and anxiety symptoms in adults when compared to a placebo ( 4).Īlthough B12 supplements are commonly taken to boost energy levels, there is currently no evidence suggesting that more B12 increases energy in people with adequate levels of this vitamin. Reduced symptoms of anxiety and depression.A review of studies found that lower levels of B12 in the blood are associated with a higher risk of developing depression, though no concrete evidence of the vitamin’s ability to improve mood is available yet ( 3). While people who consume adequate amounts of B12-rich foods and are able to properly absorb and use this nutrient don’t necessarily need to supplement, taking extra B12 has been linked to some health benefits.įor example, studies show that supplemental B12 may benefit people without a deficiency in the following ways: Vitamin B12 deficiency can lead to serious complications such as nerve damage, anemia, and fatigue, which is why those at risk should talk with their doctor about adding a high quality B12 supplement to their diet ( 2). Health conditions such as inflammatory bowel disease (IBD), certain medications, genetic mutations, age, and dietary restrictions can all contribute to an increased need for B12. Though B12 is found in many foods, such as meat, poultry, seafood, eggs, dairy products, and fortified cereals, many people don’t get enough of this important vitamin. It’s responsible for numerous functions in your body, including red blood cell formation, energy production, DNA formation, and nerve maintenance ( 1). There’s no question that vitamin B12 is essential for health. Share on Pinterest Emilija Manevska/Getty Images
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